Publications - HIV Cure Center

Publications From 2016-2021

Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jeffrey M. Jacobson, Jean-Pierre Routy, Seth Welles, Mark DeBenedette, Irina Tcherepanova, Jonathan B. Angel, David M. Asmuth, David K. Stein, Jean-Guy Baril, Mehri McKellar, David M. Margolis, Benoit Trottier, Kenneth Wood, Charles Nicolette
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2017 May 1.Published in final edited form as: J Acquir Immune Defic Syndr. 2016 May 1; 72(1): 31–38. doi: 10.1097/QAI.0000000000000926
PMCID: PMC4836975

Highlights from the Seventh International Workshop on HIV Persistence during Therapy, 8–11 December 2015, Miami, Florida, USA
David M. Margolis, Karl Salzwedel, Nicolas Chomont, Christina Psomas, Jean-Pierre Routy, Guido Poli, Alain Lafeuillade
J Virus Erad. 2016 Jan; 2(1): 57–65. Published online 2016 Jan 1.
PMCID: PMC4946700

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function
Carolina Garrido, Adam M. Spivak, Natalia Soriano-Sarabia, Mary Ann Checkley, Edward Barker, Jonathan Karn, Vicente Planelles, David M. Margolis
Front Immunol. 2016; 7: 356. Published online 2016 Sep 21. doi: 10.3389/fimmu.2016.00356
PMCID: PMC5030263

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model
Cory H. White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J. Martins, Celsa A. Spina, David M. Margolis, Douglas D. Richman, Vicente Planelles, Alberto Bosque, Christopher H. Woelk
PLoS Pathog. 2016 Nov; 12(11): e1006026. Published online 2016 Nov 29. doi: 10.1371/journal.ppat.1006026
PMCID: PMC5127598

Interrupting antiretroviral treatment in HIV cure research: scientific and ethical considerations
Samual A Garner, Stuart Rennie, Jintanat Ananworanich, Karine Dube, David M Margolis, Jeremy Sugarman, Randall Tressler, Adam Gilbertson, Liza Dawson
J Virus Erad. 2017 Apr; 3(2): 82–84. Published online 2017 Apr 1.
PMCID: PMC5384270

A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?
Michael M. Lederman, Paula M. Cannon, Judith S. Currier, Carl H. June, Hans Peter Kiem, Daniel R. Kuritzkes, Sharon R. Lewin, David M. Margolis, Joseph M. McCune, John W. Mellors, Timothy W. Schacker, Rafick P. Sekaly, Pablo Tebas, Bruce D. Walker, Daniel C. Douek
Pathog Immun. Author manuscript; available in PMC 2016 Sep 22.Published in final edited form as: Pathog Immun. 2016 Spring; 1(1): 154–164. doi: 10.20411/pai.v1i1.133
PMCID: PMC5033048

Publications Pre-2016

Acute HIV-1 Infection in the Southeastern United States: A Cohort Study
Mehri S. McKellar, Anna B. Cope, Cynthia L. Gay, Kara S. McGee, JoAnn D. Kuruc, Melissa G. Kerkau, Christopher B. Hurt, Susan A. Fiscus, Guido Ferrari, David M. Margolis, Joseph J. Eron, Charles B. Hicks
AIDS Res Hum Retroviruses. 2013 Jan; 29(1): 121–128. doi: 10.1089/aid.2012.0064
PMCID: PMC3537297

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
Celsa A. Spina, Jenny Anderson, Nancie M. Archin, Alberto Bosque, Jonathan Chan, Marylinda Famiglietti, Warner C. Greene, Angela Kashuba, Sharon R. Lewin, David M. Margolis, Matthew Mau, Debbie Ruelas, Suha Saleh, Kotaro Shirakawa, Robert F. Siliciano, Akul Singhania, Paula C. Soto, Valeri H. Terry, Eric Verdin, Christopher Woelk, Stacey Wooden, Sifei Xing, Vicente Planelles
PLoS Pathog. 2013 Dec; 9(12): e1003834. Published online 2013 Dec 26. doi: 10.1371/journal.ppat.1003834
PMCID: PMC3873446

Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection
Nancie M. Archin, Naveen K. Vaidya, JoAnn D. Kuruc, Abigail L. Liberty, Ann Wiegand, Mary F. Kearney, Myron S. Cohen, John M. Coffin, Ronald J. Bosch, Cynthia L. Gay, Joseph J. Eron, David M. Margolis, Alan S. Perelson
Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24): 9523–9528. Published online 2012 May 29. doi: 10.1073/pnas.1120248109
PMCID: PMC3386138

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
Amanda M. Crooks, Rosalie Bateson, Anna B. Cope, Noelle P. Dahl, Morgan K. Griggs, JoAnn D. Kuruc, Cynthia L. Gay, Joseph J. Eron, David M. Margolis, Ronald J. Bosch, Nancie M. Archin
J Infect Dis. 2015 Nov 1; 212(9): 1361–1365. Published online 2015 Apr 15. doi: 10.1093/infdis/jiv218
PMCID: PMC4601910

Rifaximin has a Marginal Impact on Microbial Translocation, T-cell Activation and Inflammation in HIV-Positive Immune Non-responders to Antiretroviral Therapy – ACTG A5286
Allan R. Tenorio, Ellen S. Chan, Ronald J. Bosch, Bernard J. C. Macatangay, Sarah W. Read, Suria Yesmin, Babafemi Taiwo, David M. Margolis, Jeffrey M. Jacobson, Alan L. Landay, Cara C. Wilson, John W. Mellors, Ali Keshavarzian, Benigno Rodriguez, Mariam Aziz, Rachel Presti, Steven Deeks, Ruth Ebiasah, Laurie Myers, LuAnn Borowski, Jill Plants, David A. Palm, Derek Weibel, Beverly Putnam, Elizabeth Lindsey, Amy Player, Mary Albrecht, Andrea Kershaw, Paul Sax, Cheryl Keenan, Patricia Walton, Jane Baum, Todd Stroberg, Valery Hughes, Laura Coster, Princy N. Kumar, Michael T. Yin, Jolene Noel-Connor, Pablo Tebas, Aleshia Thomas, Charles E. Davis, Jr., Robert R. Redfield, Jr., Amy Sbrolla, Teri Flynn, Traci Davis, Kim Whitely, Baljinder Singh, Shobha Swaminathan, Donna McGregor, Frank Palella, Judith Aberg, Karen Cavanagh, Jorge L. Santana Bagur, Olga Méndez Flores, Janice Fritsche, Beverly Sha, Debbie Slamowitz, Sandra Valle, Karen Tashima, Helen Patterson, Heather Harber, Michael Para, Molly Eaton, Dale Maddox, Judith Currier, Vanessa Cajahuaringa, Annie Luetkemeyer, Jay Dwyer, Carl J. Fichtenbaum, Michelle Saemann, Graham Ray, Thomas Campbell, Margaret A. Fischl, Hector Bolivar, Jonathan Oakes, Miriam Chicurel-Bayard, Christine Tripoli, D. Renee Weinman, Mary Adams, Christine Hurley, Shelia Dunaway, Sheryl Storey, Michael Klebert, Michael Royal
J Infect Dis. 2015 Mar 1; 211(5): 780–790. Published online 2014 Sep 11. doi: 10.1093/infdis/jiu515
PMCID: PMC4334803

Expanded Cytotoxic T-cell Lymphocytes Target the Latent HIV Reservoir
Julia A. Sung, Sharon Lam, Carolina Garrido, Nancie Archin, Cliona M. Rooney, Catherine M. Bollard, David M. Margolis
J Infect Dis. 2015 Jul 15; 212(2): 258–263. Published online 2015 Jan 13. doi: 10.1093/infdis/jiv022
PMCID: PMC4490234

Eradicating HIV-1 infection: seeking to clear a persistent pathogen
Nancie M. Archin, Julia Marsh Sung, Carolina Garrido, Natalia Soriano-Sarabia, David M. Margolis
Nat Rev Microbiol. Author manuscript; available in PMC 2015 Nov 1.Published in final edited form as: Nat Rev Microbiol. 2014 Nov; 12(11): 750–764. doi: 10.1038/nrmicro3352
PMCID: PMC4383747

No Effect of Raltegravir Intensification on Viral Replication Markers in the Blood of HIV-1-infected Patients Receiving Antiretroviral Therapy
Rajesh T. Gandhi, Robert W. Coombs, Ellen S. Chan, Ronald J. Bosch, Lu Zheng, David M. Margolis, Sarah Read, Beatrice Kallungal, Ming Chang, Erin A. Goecker, Ann Wiegand, Mary Kearney, Jeffrey M. Jacobson, Richard D’Aquila, Michael M. Lederman, John W. Mellors, Joseph J. Eron
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2013 Mar 1.Published in final edited form as: J Acquir Immune Defic Syndr. 2012 Mar 1; 59(3): 229–235. doi: 10.1097/QAI.0b013e31823fd1f2
PMCID: PMC3423091

Regimen Simplification to Atazanavir-Ritonavir Alone as Maintenance Antiretroviral Therapy: Final 48-Week Clinical and Virologic Outcomes
Timothy J. Wilkin, John E. McKinnon, A. Gregory DiRienzo, Katie Mollan, Courtney V. Fletcher, David M. Margolis, Barbara Bastow, Gary Thal, William Woodward, Catherine Godfrey, Ann Wiegand, Frank Maldarelli, Sarah Palmer, John M. Coffin, John W. Mellors, Susan Swindells
J Infect Dis. Author manuscript; available in PMC 2009 May 12.Published in final edited form as: J Infect Dis. 2009 Mar 15; 199(6): 866–871. doi: 10.1086/597119
PMCID: PMC2680942

The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial
Rajesh T. Gandhi, Lu Zheng, Ronald J. Bosch, Ellen S. Chan, David M. Margolis, Sarah Read, Beatrice Kallungal, Sarah Palmer, Kathy Medvik, Michael M. Lederman, Nadia Alatrakchi, Jeffrey M. Jacobson, Ann Wiegand, Mary Kearney, John M. Coffin, John W. Mellors, Joseph J. Eron, on behalf of the AIDS Clinical Trials Group A5244 team
PLoS Med. 2010 Aug; 7(8): e1000321. Published online 2010 Aug 10. doi: 10.1371/journal.pmed.1000321Correction in: PLoS Med. 2011 Aug; 8(8): 10.1371/annotation/fcb608e3-54c2-4cf8-b1d9-34e86196013f.
PMCID: PMC2919424

Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2−/−γc−/− Mouse
Shailesh K. Choudhary, Naser L. Rezk, William L. Ince, Manzoor Cheema, Liguo Zhang, Lishan Su, Ronald Swanstrom, Angela D. M. Kashuba, David M. Margolis
J Virol. 2009 Aug; 83(16): 8254–8258. Published online 2009 Jun 3. doi: 10.1128/JVI.00580-09
PMCID: PMC2715775

Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection
Marc C. Levesque, M. Anthony Moody, Kwan-Ki Hwang, Dawn J. Marshall, John F. Whitesides, Joshua D. Amos, Thaddeus C. Gurley, Sallie Allgood, Benjamin B. Haynes, Nathan A. Vandergrift, Steven Plonk, Daniel C. Parker, Myron S. Cohen, Georgia D. Tomaras, Paul A. Goepfert, George M. Shaw, Jörn E. Schmitz, Joseph J. Eron, Nicholas J. Shaheen, Charles B. Hicks, Hua-Xin Liao, Martin Markowitz, Garnett Kelsoe, David M. Margolis, Barton F. Haynes
PLoS Med. 2009 Jul; 6(7): e1000107. Published online 2009 Jul 7. doi: 10.1371/journal.pmed.1000107
PMCID: PMC2702159

Efficacy of NNRTI-Based Antiretroviral Therapy Initiated During Acute HIV Infection
Cynthia L. Gay, Ashley J. Mayo, Chelu K. Mfalila, Haitao Chu, Anna C. Barry, JoAnn D. Kuruc, Kara S. McGee, Melissa Kerkau, Joe Sebastian, Susan A. Fiscus, David M. Margolis, Charles B. Hicks, Guido Ferrari, Joseph J. Eron
AIDS. Author manuscript; available in PMC 2013 Feb 11.Published in final edited form as: AIDS. 2011 Apr 24; 25(7): 941–949. doi: 10.1097/QAD.0b013e3283463c07
PMCID: PMC3569481

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
Nancy M. Archin, Joseph J. Eron, Sarah Palmer, Anne Hartmann-Duff, Jeffery A. Martinson, Ann Wiegand, Nicholas Bandarenko, John L. Schmitz, Ronald J. Bosch, Alan L. Landay, John M. Coffin, David M. Margolis
AIDS. Author manuscript; available in PMC 2013 Dec 16.Published in final edited form as: AIDS. 2008 Jun 19; 22(10): 10.1097/QAD.0b013e3282fd6df4. doi: 10.1097/QAD.0b013e3282fd6df4
PMCID: PMC3863687

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype
Meagan O’Brien, Olivier Manches, Rachel Lubong Sabado, Sonia Jimenez Baranda, Yaming Wang, Isabelle Marie, Linda Rolnitzky, Martin Markowitz, David M. Margolis, David Levy, Nina Bhardwaj
J Clin Invest. 2011 Mar 1; 121(3): 1088–1101. Published online 2011 Feb 21. doi: 10.1172/JCI44960
PMCID: PMC3049388

Predictors of Residual Viremia in Patients on Long-term Suppressive Antiretroviral Therapy
Lu Zheng, Ronald J. Bosch, Ellen S. Chan, Sarah Read, Mary Kearney, David M. Margolis, John W. Mellors, Joseph J. Eron, Rajesh T. Gandhi
Antivir Ther. Author manuscript; available in PMC 2014 Jan 1.Published in final edited form as: Antivir Ther. 2013; 18(1): 39–43. Published online 2012 Aug 22. doi: 10.3851/IMP2323
PMCID: PMC3578982

Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection
Natalia Soriano-Sarabia, Nancie M. Archin, Rosalie Bateson, Noelle P. Dahl, Amanda M. Crooks, JoAnn D. Kuruc, Carolina Garrido, David M. Margolis
PLoS Pathog. 2015 Oct; 11(10): e1005201. Published online 2015 Oct 16. doi: 10.1371/journal.ppat.1005201
PMCID: PMC4608739

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat
Nancy M. Archin, Rosalie Bateson, Manoj K. Tripathy, Amanda M. Crooks, Kuo-Hsiung Yang, Noelle P. Dahl, Mary F. Kearney, Elizabeth M. Anderson, John M. Coffin, Matthew C. Strain, Douglas D. Richman, Kevin R. Robertson, Angela D. Kashuba, Ronald J. Bosch, Daria J. Hazuda, Joann D. Kuruc, Joseph J. Eron, David M. Margolis
J Infect Dis. 2014 Sep 1; 210(5): 728–735. Published online 2014 Mar 11. doi: 10.1093/infdis/jiu155
PMCID: PMC4148603

H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells
Manoj K. Tripathy, Mary E. M. McManamy, Brandon D. Burch, Nancie M. Archin, David M. Margolis
J Virol. 2015 Aug 15; 89(16): 8392–8405. Published online 2015 Jun 3. doi: 10.1128/JVI.00572-15
PMCID: PMC4524215

HLA-B*57 Elite Suppressor and Chronic Progressor HIV-1 Isolates Replicate Vigorously and Cause CD4+ T Cell Depletion in Humanized BLT Mice
Maria Salgado, Michael D. Swanson, Christopher W. Pohlmeyer, Robert W. Buckheit, III, Jin Wu, Nancie M. Archin, Thomas M. Williams, David M. Margolis, Robert F. Siliciano, J. Victor Garcia, Joel N. Blankson
J Virol. 2014 Mar; 88(6): 3340–3352. doi: 10.1128/JVI.03380-13
PMCID: PMC3957943

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
Hua-Xin Liao, Xi Chen, Supriya Munshaw, Ruijun Zhang, Dawn J. Marshall, Nathan Vandergrift, John F. Whitesides, Xiaozhi Lu, Jae-Sung Yu, Kwan-Ki Hwang, Feng Gao, Martin Markowitz, Sonya L. Heath, Katharine J. Bar, Paul A. Goepfert, David C. Montefiori, George C. Shaw, S. Munir Alam, David M. Margolis, Thomas N. Denny, Scott D. Boyd, Eleanor Marshal, Michael Egholm, Birgitte B. Simen, Bozena Hanczaruk, Andrew Z. Fire, Gerald Voss, Garnett Kelsoe, Georgia D. Tomaras, M. Anthony Moody, Thomas B. Kepler, Barton F. Haynes
J Exp Med. 2011 Oct 24; 208(11): 2237–2249. doi: 10.1084/jem.20110363
PMCID: PMC3201211

Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells
Julia A.M. Sung, Joy Pickeral, Liqin Liu, Sherry A. Stanfield-Oakley, Chia-Ying Kao Lam, Carolina Garrido, Justin Pollara, Celia LaBranche, Mattia Bonsignori, M. Anthony Moody, Yinhua Yang, Robert Parks, Nancie Archin, Brigitte Allard, Jennifer Kirchherr, JoAnn D. Kuruc, Cynthia L. Gay, Myron S. Cohen, Christina Ochsenbauer, Kelly Soderberg, Hua-Xin Liao, David Montefiori, Paul Moore, Syd Johnson, Scott Koenig, Barton F. Haynes, Jeffrey L. Nordstrom, David M. Margolis, Guido Ferrari
J Clin Invest. 2015 Nov 2; 125(11): 4077–4090. Published online 2015 Sep 28. doi: 10.1172/JCI82314
PMCID: PMC4639974

Gold nanoparticles to improve HIV drug delivery
Carolina Garrido, Carrie A Simpson, Noelle P Dahl, Jamee Bresee, Daniel C Whitehead, Erick A Lindsey, Tyler L Harris, Candice A Smith, Carly J Carter, Daniel L Feldheim, Christian Melander, David M Margolis
Future Med Chem. 2015 Jul; 7(9): 1097–1107. doi: 10.4155/fmc.15.57
PMCID: PMC4501014

Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2−/− γc−/− Mouse
Shailesh K. Choudhary, Nancie M. Archin, Manzoor Cheema, Noelle P. Dahl, J. Victor Garcia, David M. Margolis
J Virol. 2012 Jan; 86(1): 114–120. doi: 10.1128/JVI.05590-11
PMCID: PMC3255863

Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T cell activation
Michael J. Vinikoor, Anna Cope, Cynthia L. Gay, Guido Ferrari, Kara S. McGee, Joann D. Kuruc, Jeffrey L. Lennox, David M. Margolis, Charles B. Hicks, Joseph J. Eron
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2014 Apr 15.Published in final edited form as: J Acquir Immune Defic Syndr. 2013 Apr 15; 62(5): 505–508. doi: 10.1097/QAI.0b013e318285cd33
PMCID: PMC3683110

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART
Paul W. Denton, Julie M. Long, Stephen W. Wietgrefe, Craig Sykes, Rae Ann Spagnuolo, Olivia D. Snyder, Katherine Perkey, Nancie M. Archin, Shailesh K. Choudhary, Kuo Yang, Michael G. Hudgens, Ira Pastan, Ashley T. Haase, Angela D. Kashuba, Edward A. Berger, David M. Margolis, J. Victor Garcia
PLoS Pathog. 2014 Jan; 10(1): e1003872. Published online 2014 Jan 9. doi: 10.1371/journal.ppat.1003872
PMCID: PMC3887103

Generation of HIV Latency in Humanized BLT Mice
Paul W. Denton, Rikke Olesen, Shailesh K. Choudhary, Nancy M. Archin, Angela Wahl, Michael D. Swanson, Morgan Chateau, Tomonori Nochi, John F. Krisko, Rae Ann Spagnuolo, David M. Margolis, J. Victor Garcia
J Virol. 2012 Jan; 86(1): 630–634. doi: 10.1128/JVI.06120-11
PMCID: PMC3255928

Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells
Jeffrey A. Anderson, Nancie M. Archin, William Ince, Daniel Parker, Ann Wiegand, John M. Coffin, JoAnn Kuruc, Joseph Eron, Ronald Swanstrom, David M. Margolis
J Virol. 2011 May; 85(10): 5220–5223. doi: 10.1128/JVI.00284-11
PMCID: PMC3126162

Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection
Nancie M. Archin, Manzoor Cheema, Daniel Parker, Ann Wiegand, Ronald J. Bosch, John M. Coffin, Joseph Eron, Myron Cohen, David M. Margolis
PLoS One. 2010; 5(2): e9390. Published online 2010 Feb 23. doi: 10.1371/journal.pone.0009390
PMCID: PMC2826423

Translational Challenges in Targeting Latent HIV infection and the CNS reservoir problem
Carolina Garrido, David M. Margolis
J Neurovirol. Author manuscript; available in PMC 2016 Jun 1.Published in final edited form as: J Neurovirol. 2015 Jun; 21(3): 222–226. Published online 2014 Jul 25. doi: 10.1007/s13365-014-0269-z
PMCID: PMC4305502

Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170)
Robert J. McLinden, Robert M. Paris, Victoria R. Polonis, Nicole C. Close, Zhaohui Su, Cecilia M. Shikuma, David M. Margolis, Jerome H. Kim
AIDS. Author manuscript; available in PMC 2012 Nov 25.Published in final edited form as: AIDS. 2012 Jul 17; 26(11): 1452. doi: 10.1097/QAD.0b013e3283550b8e
PMCID: PMC3505760

Characterizing the switching thresholds of magnetophoretic transistors
Roozbeh Abedini-Nassab, Daniel Y. Joh, Melissa A. Van Heest, John S. Yi, Cody Baker, Zohreh Taherifard, David M. Margolis, Victor Garcia-Martinez, Ashutosh Chilkoti, David M. Murdoch, Benjamin B. Yellen
Adv Mater. Author manuscript; available in PMC 2015 Nov 12.Published in final edited form as: Adv Mater. 2015 Oct; 27(40): 6176–6180. Published online 2015 Sep 9. doi: 10.1002/adma.201502352
PMCID: PMC4642725

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
Camellia Banerjee, Nancie Archin, Daniel Michaels, Anna C. Belkina, Gerald V. Denis, James Bradner, Paola Sebastiani, David M. Margolis, Monty Montano
J Leukoc Biol. 2012 Dec; 92(6): 1147–1154. doi: 10.1189/jlb.0312165
PMCID: PMC3501896

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles
Mary-Catherine Bowman, T. Eric Ballard, Christopher J. Ackerson, Daniel L. Feldheim, David M. Margolis, Christian Melander
J Am Chem Soc. Author manuscript; available in PMC 2010 Aug 5.Published in final edited form as: J Am Chem Soc. 2008 Jun 4; 130(22): 6896–6897. Published online 2008 May 13. doi: 10.1021/ja710321g
PMCID: PMC2916654

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation
Sifei Xing, Cynthia K. Bullen, Neeta S. Shroff, Liang Shan, Hung-Chih Yang, Jordyn L. Manucci, Shridhar Bhat, Hao Zhang, Joseph B. Margolick, Thomas C. Quinn, David M. Margolis, Janet D. Siliciano, Robert F. Siliciano
J Virol. 2011 Jun; 85(12): 6060–6064. doi: 10.1128/JVI.02033-10
PMCID: PMC3126325

Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation
Camille L Novis, Nancie M Archin, Maria J Buzon, Eric Verdin, June L Round, Mathias Lichterfeld, David M Margolis, Vicente Planelles, Alberto Bosque
Retrovirology. 2013; 10: 119. Published online 2013 Oct 24. doi: 10.1186/1742-4690-10-119
PMCID: PMC3826617

Quantitation of Replication-Competent HIV-1 in Populations of Resting CD4+ T Cells
Natalia Soriano-Sarabia, Rosalie E. Bateson, Noelle P. Dahl, Amanda M. Crooks, JoAnn D. Kuruc, David M. Margolis, Nancie M. Archin
J Virol. 2014 Dec; 88(24): 14070–14077. doi: 10.1128/JVI.01900-14
PMCID: PMC4249150

Emerging strategies to deplete the HIV reservoir
Nancie M. Archin, David M. Margolis
Curr Opin Infect Dis. Author manuscript; available in PMC 2014 May 22.Published in final edited form as: Curr Opin Infect Dis. 2014 Feb; 27(1): 29–35. doi: 10.1097/QCO.0000000000000026
PMCID: PMC4031321

Therapy for latent human immunodeficiency virus type 1 infection: the role of histone deacetylase inhibitors
Mary E Manson McManamy, Shweta Hakre, Eric M Verdin, David M Margolis
Antivir Chem Chemother. Author manuscript; available in PMC 2015 Jan 29.Published in final edited form as: Antivir Chem Chemother. 2014 Jan 29; 23(4): 145–149. Published online 2014 Jan 29. doi: 10.3851/IMP2551
PMCID: PMC3947511

Change-Point Models to Estimate the Limit of Detection
Ryan C. May, Haitao Chu, Joseph G. Ibrahim, Michael G. Hudgens, Abigail C. Lees, David M. Margolis
Stat Med. Author manuscript; available in PMC 2014 Dec 10.Published in final edited form as: Stat Med. 2013 Dec 10; 32(28): 4995–5007. Published online 2013 Jun 20. doi: 10.1002/sim.5872
PMCID: PMC3858526

Combined approaches for HIV cure
David M. Margolis, Daria J. Hazuda
Curr Opin HIV AIDS. Author manuscript; available in PMC 2014 May 1.Published in final edited form as: Curr Opin HIV AIDS. 2013 May; 8(3): 230–235. doi: 10.1097/COH.0b013e32835ef089
PMCID: PMC3966301

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
Julia Friedman, Won-Kyung Cho, Chung K. Chu, Kara S. Keedy, Nancie M. Archin, David M. Margolis, Jonathan Karn
J Virol. 2011 Sep; 85(17): 9078–9089. doi: 10.1128/JVI.00836-11
PMCID: PMC3165831

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency
Shailesh K. Choudhary, David M. Margolis
Annu Rev Pharmacol Toxicol. Author manuscript; available in PMC 2014 Mar 19.Published in final edited form as: Annu Rev Pharmacol Toxicol. 2011; 51: 397–418. doi: 10.1146/annurev-pharmtox-010510-100237
PMCID: PMC3958947

Histone deacetylase inhibitors and HIV latency
David M. Margolis
Curr Opin HIV AIDS. Author manuscript; available in PMC 2012 Jan 1.Published in final edited form as: Curr Opin HIV AIDS. 2011 Jan; 6(1): 25–29. doi: 10.1097/COH.0b013e328341242d
PMCID: PMC3079555

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid
Nancie M. Archin, Amy Espeseth, Daniel Parker, Manzoor Cheema, Daria Hazuda, David M. Margolis
AIDS Res Hum Retroviruses. 2009 Feb; 25(2): 207–212. doi: 10.1089/aid.2008.0191
PMCID: PMC2853863

CD4+ T-Cell Decline after the Interruption of Antiretroviral Therapy in ACTG A5170 Is Predicted by Differential Expression of Genes in the Ras Signaling Pathway
Maryanne T. Vahey, Zhining Wang, Zhaohui Su, Martin E. Nau, Amy Krambrink, Daniel J. Skiest, David M. Margolis
AIDS Res Hum Retroviruses. 2008 Aug; 24(8): 1047–1066. doi: 10.1089/aid.2008.0059
PMCID: PMC3139520

Detection of Nonnucleoside Reverse-Transcriptase Inhibitor–Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy
C. Bradley Hare, John Mellors, Amy Krambrink, Zhaohui Su, Daniel Skiest, David M. Margolis, Sheran S. Patel, Douglas Barnas, Lisa Frenkel, Robert W. Coombs, Francesca Aweeka, Gene D. Morse, David W. Haas, Valerie Boltz, Sarah Palmer, John Coffin, Diane V. Havlir
Clin Infect Dis. Author manuscript; available in PMC 2008 Nov 25.Published in final edited form as: Clin Infect Dis. 2008 Aug 1; 47(3): 421–424. doi: 10.1086/589867
PMCID: PMC2586907

c-Myc and Sp1 Contribute to Proviral Latency by Recruiting Histone Deacetylase 1 to the Human Immunodeficiency Virus Type 1 Promoter
Guochun Jiang, Amy Espeseth, Daria J. Hazuda, David M. Margolis
J Virol. 2007 Oct; 81(20): 10914–10923. Published online 2007 Aug 1. doi: 10.1128/JVI.01208-07
PMCID: PMC2045540

Dose-Responsive Gene Expression in Suberoylanilide Hydroxamic Acid (SAHA) Treated Resting CD4+ T Cells
Brian Reardon, Nadejda Beliakova-Bethell, Celsa A. Spina, Akul Singhania, David M. Margolis, Douglas R. Richman, Christopher H. Woelk
AIDS. Author manuscript; available in PMC 2016 Nov 1.Published in final edited form as: AIDS. 2015 Nov; 29(17): 2235–2244. doi: 10.1097/QAD.0000000000000839
PMCID: PMC4917679

Words Matter: Discussing Research Towards an HIV Cure in Research and Clinical Contexts
Joseph D. Tucker, Paul A. Volberding, David M. Margolis, Stuart Rennie, Françoise Barré-Sinoussi
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2015 Nov 1.Published in final edited form as: J Acquir Immune Defic Syndr. 2014 Nov 1; 67(3): e110–e111. doi: 10.1097/QAI.0000000000000305
PMCID: PMC4199082

Framing expectations in early HIV cure research
Karine Dubé, Gail E. Henderson, David M. Margolis
Trends Microbiol. Author manuscript; available in PMC 2014 Oct 18.Published in final edited form as: Trends Microbiol. 2014 Oct; 22(10): 547–549. doi: 10.1016/j.tim.2014.08.003
PMCID: PMC4201845

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection
Kirston M. Barton, Nancie M. Archin, Kara S. Keedy, Amy S. Espeseth, Yan-ling Zhang, Jennifer Gale, Florence F. Wagner, Edward B. Holson, David M. Margolis
PLoS One. 2014; 9(8): e102684. Published online 2014 Aug 19. doi: 10.1371/journal.pone.0102684
PMCID: PMC4138023

Eradication Therapies for HIV Infection: Time to Begin Again
David M. Margolis
AIDS Res Hum Retroviruses. 2011 Apr; 27(4): 347–353. doi: 10.1089/aid.2011.0017
PMCID: PMC3065332

Treatments for persistent HIV infection: the road ahead
David M Margolis
Retrovirology. 2010; 7(Suppl 1): I17. Published online 2010 May 11. doi: 10.1186/1742-4690-7-S1-I17
PMCID: PMC3315953

Treatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174
Kimberly Smith, Lu Zheng, Ronald Bosch, David M. Margolis, Allan Tenorio, Laura Napolitano, Michael Saag, Elizabeth Connick, Barry Gross, Isaac Francis, Hernan Valdez, Norma Muurahainen, Vicky Stocker, Richard Pollard
AIDS Res Hum Retroviruses. 2010 Apr; 26(4): 425–432. doi: 10.1089/aid.2009.0052Correction in: AIDS Res Hum Retroviruses. 2010 Jul 1; 26(7): 839.
PMCID: PMC2864047

Therapy for Persistent HI
Kara S. Keedy, Angela D. Kashuba, David M. Margolis
Trends Pharmacol Sci. Author manuscript; available in PMC 2011 May 1.Published in final edited form as: Trends Pharmacol Sci. 2010 May; 31(5): 206–211. Published online 2010 Mar 5. doi: 10.1016/j.tips.2010.02.001
PMCID: PMC2862871

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
Nancie M. Archin, Kara S. Keedy, Amy Espeseth, Herbert Dang, Daria J. Hazuda, David M. Margolis
AIDS. Author manuscript; available in PMC 2013 Oct 28.Published in final edited form as: AIDS. 2009 Sep 10; 23(14): 10.1097/QAD.0b013e32832ec1dc. doi: 10.1097/QAD.0b013e32832ec1dc
PMCID: PMC3809117

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression
Kara S. Keedy, Nancie M. Archin, Adam T. Gates, Amy Espeseth, Daria J. Hazuda, David M. Margolis
J Virol. 2009 May; 83(10): 4749–4756. Published online 2009 Mar 11. doi: 10.1128/JVI.02585-08
PMCID: PMC2682072

Improved Measures of Quality of Life, Lipid Profile and Lipoatrophy after Treatment Interruption in HIV-Infected Patients with Immune Preservation: results of ACTG 5170
Daniel J. Skiest, Amy Krambrink, Zhaohui Su, Kevin R. Robertson, David M. Margolis, the A5170 study team
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2009 Feb 2.Published in final edited form as: J Acquir Immune Defic Syndr. 2008 Dec 1; 49(4): 377–383. doi: 10.1097/QAI.0b013e31818cde21
PMCID: PMC2634828